Hydrogen Bromide → HCID 67192122, compound

Participants

Reaction Steps

HBr in acetic acid (30 mL) was added to 1-benzyl-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (I-3b: 2.5 g) and the resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was basified with NaHCO3 solution and partitioned between ice water and ethyl acetate. The organic layer was concentrated to afford the crude product. Purification by column chromatography on silica gel (60% ethylacetate in hexane) afforded 1.5 g of the product (75% yield).

Provenance & Evidence