HCID 58380528, compound → 2-Benzyloxymethyl-cyclopropanesulfonic acid [7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-a]pyridin-8-yl]-amide

Participants

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 7A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 0.08 g, 0.0002 mol) in dry pyridine (2 ml) was reacted with 2-benzyloxymethyl-cyclopropanesulfonyl chloride (57 mg, 0.0002 mol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in DCM) afforded 51 mg of the product (21% yield).

Provenance & Evidence