HCID 58380528, compound → HCID 58380571, compound

Participants

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 7A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 0.35 g, 0.873 mmol) in pyridine (3 mL) was reacted with 1-benzyloxymethyl-cyclopropanesulfonyl chloride (0.34 mg, 1.30 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 0.27 g of the product (50% yield).

Provenance & Evidence