HCID 58380528, compound → 3-Benzyloxy-cyclobutanesulfonic acid [7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-a]pyridin-8-yl]-amide

Participants

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 7A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 0.53 g, 1.0 mmol) in pyridine (4 mL) was reacted with 3-benzyloxy-cyclobutanesulfonyl chloride (0.179 mg, 1.2 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in DCM) afforded 195 mg of the product (23.8% yield).

Provenance & Evidence