Cyclobutanesulfonyl chloride → HCID 52934325, compound

Participants

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 7A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 400 mg, 0.99 mmol) in pyridine (4 ml) was reacted with cyclobutanesulfonyl chloride (274 mg, 1.7 mmol) to afford the crude product. Purification by preparative HPLC afforded 26 mg of the product (5% yield).

Provenance & Evidence