Benzyl Bromide → Butyl 3-(1,3-bis(benzyloxy)propan-2-yl)cyclobutane-1-sulfonate

Participants

Reaction Steps

Using the same reaction conditions, procedure and work up as described Intermediate I-25a (below), butyl 3-(1,3-dihydroxypropan-2-yl)cyclobutane-1-sulfonate (0.13 g, 0.489 mmol) was reacted with benzyl bromide (0.13 mL, 1.075 mmol), 60% NaH (60 mg, 1.467 mmol) and THF (5 mL) to afford the crude product. Purification by column chromatography on silica gel (8% ethyl acetate in hexane) afforded 0.07 g of the product (78% yield).

Provenance & Evidence