HCID 58380528, compound → HCID 67345136, compound

Participants

Reaction Steps

Using the same reaction conditions and procedure as described for the preparation of Example 7A, 8-Amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 0.22 g, 0.539 mmol) was reacted with 3-(1,3-bis(benzyloxy)propan-2-yl)cyclobutane-1-sulfonyl chloride (0.21 g, 0.539 mmol) in dry pyridine (2 mL) to afford the crude product. Purification by column chromatography on silica gel (80% ethyl acetate in hexane) afforded 0.3 g of the product (71% yield). LCMS: 80%, m/z=773 (M+1)

Provenance & Evidence