Potassium thiocyanate → 3-(2-Thiocyanatoethyl)oxetane

HRID 1259413Notes

Reaction equation

HRID 1259413 reaction equation
CC1C=CC(S(O[CH2:12][CH2:13][CH:14]2[CH2:17][O:16][CH2:15]2)(=O)=O)=CC=1.[C:18]([S-:20])#[N:19].[K+]>C(O)C>[S:20]([CH2:12][CH2:13][CH:14]1[CH2:15][O:16][CH2:17]1)[C:18]#[N:19]

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 58380558HCID 58380558, compound

Product 1

HCID 583805923-(2-Thiocyanatoethyl)oxetaneYield 304.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using the same reaction conditions, procedure and work up as described for the preparation of Intermediate (I-16b), 2-(oxetan-3-yl)ethyl 4-methyl-benzenesulfonate (1 g, 3.90 mmol) was reacted with KSCN (0.75 g, 7.81 mmol) in ethanol (20 mL) to afford 1.7 g of the crude product which was used for the next step without further purification.

Workup

  1. customthe same reaction conditions, procedure

Sources & evidence

ORD record
ord-05dde558d8e84b55af7f44b8535c996a
Source dataset
uspto-grants-2013_06
Patent number
US08466289B2

Reaction notes

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