Ethanethiol → HCID 52934559, compound

Participants

Reaction Conditions

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 21A, 1-benzyloxymethyl-cyclopropanesulfonic acid [7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridin-8-yl]-amide (0.2 g, 0.321 mmol) was reacted with BF3OEt2(0.79 mL, 6.24 mmol) and ethane thiol (0.2 mL, 3.21 mmol). The resulting mixture was stirred at 40° C. for 6 hours. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 100 mg of the product (55% yield).

Provenance & Evidence