Cyclobutanesulfonyl chloride → HCID 52934780, compound

Participants

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 19A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (I-19f: 0.1 g, 0.23 mmol) in pyridine (2 mL) was reacted with cyclobutanesulfonyl chloride (0.04 g, 0.20 mmol) to afford the crude product. Purification by preparative HPLC afforded 15 mg of the product (12% yield).

Provenance & Evidence