Hydrochloric Acid → 8-Amino-7-(2-fluoro-4-iodo-phenylamino)-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one

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Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Intermediate (I-19f), 7-(2-fluoro-4-iodo-phenylamino)-8-nitro-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (0.08 g, 0.181 mmol) in ethanol (2 mL) was reacted with SnCl2.H2O (0.12 g, 0.541 mmol) and concentrated HCl (0.5 mL) to afford 0.08 g of crude product which was used in the next step without further purification. LCMS: 59%, m/z=403.9 (M+1).

Provenance & Evidence