Cyclopropanesulfonyl chloride → HCID 52934781, compound

Participants

Reaction Steps

Using the same reaction conditions and workup as described for the preparation of Example 19A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (0.08 g, 0.199 mmol) in pyridine (1 mL) was reacted with cyclopropylsulfonyl chloride (33 mg, 0.238 mmol) to afford the crude product. Purification by preparative HPLC afforded 20 mg of the product (20% yield).

Provenance & Evidence