HCID 178493840, compound → HCID 178493838, compound

Participants

Reaction Steps

tert-Butyl 2-[2-({7-methoxy-5-[(pyridin-3-ylcarbonyl)amino]-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl}oxy)ethyl]morpholine-4-carboxylate (650 mg, 1.44 mmol) was dissolved in trifluoroacetic acid (10 mL) and stirred at rt for 4 h. The reaction mixture was concentrated under reduced pressure, and the resulting oil was diluted with methanol (1 mL) and pulled through a silica bound-NH2 cartridge. The solution was concentrated under reduced pressure to give the title compound as a solid (45 mg, 69%): HPLC MS RT=0.21 min, MH+=451.1; 1H NMR (DMSO-d6) δ: 12.8-12.7 (1H, br s), 9.32 (1H, s), 8.73 (1H, d), 8.46 (1H, d), 7.60 (1H, d), 7.54-7.49 (1H, m), 7.06 (1H, d) 4.22-3.99 (6H, m), 3.94 (3H, s), 3.78 (1H, d), 3.66-3.58 (1H, m), 3.47 (1H, t), 2.95 (1H, d), 2.82-2.65 (2H, m), 1.98-1.78 (2H, m).

Provenance & Evidence