HCID 11222558, compound → HCID 66840965, compound

Participants

Reaction Steps

According to the process described in Example 2.2, the peptide coupling performed between 425 mg (1 mmol) of 6-{4-chloro-3-[3-(dimethylamino)propoxy]phenyl}-5-(2-methylphenyl)pyridine-2-carboxylic acid (Example 4.2) and 206 mg (2.05 mmol) of tert-butyl(3S)-3-amino-4,4-dimethylpentanoate (J. Org. Chem., 1999, 64, 6411-6417) gives 390 mg of (3S)-3-({[6-{4-chloro-3-[3-(dimethylamino)propoxy]phenyl}-5-(2-methylphenyl)pyridin-2-yl]carbonyl}amino)-4,4-dimethylpentanoic acid hydrochloride in the form of a white powder.

Provenance & Evidence