HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Fluoro-2-hydroxyphenyl)-1-pentylindolin-2-one → 3-(5-bromo-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Fluoro-2-hydroxyphenyl)-1-pentylindolin-2-one | HCID 58872460 | — |
| Reactant | 3-(5-bromo-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-one | HCID 58872536 | — |
| Product | 3-(5-bromo-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one | HCID 58872482 | — |
Reaction Steps
Following the procedure as described in PREPARATION 14C, and making non-critical variations to replace 3-(5-fluoro-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-one with 3-(5-bromo-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-one, the title compound was obtained: MS (ES+) m/z 386 (M−17), 388 (M−17), 426 (M+23), 428 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466188B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-9037810aaa514447b892b47a4eb424f6 |
| Source note | uspto-grants-2013_06 |