HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sesamol → 3-(4-chloro-5-fluoro-2-hydroxyphenyl)-3-hydroxy-1-pentyl-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sesamol | HCID 68289 | — |
| Reactant | 3-Chloro-4-fluorophenol | HCID 75790 | — |
| Reactant | 1-Pentyl-1H-indole-2,3-dione | HCID 1581092 | — |
| Reactant | 4-bromo-1-pentyl-1H-indole-2,3-dione | HCID 28492458 | — |
| Product | 3-(4-chloro-5-fluoro-2-hydroxyphenyl)-3-hydroxy-1-pentyl-1,3-dihydro-2H-indol-2-one | HCID 58872497 | — |
Reaction Steps
Following the procedure as described in PREPARATION 1C, and making non-critical variations to replace 4-bromo-1-pentyl-1H-indole-2,3-dione with 1-pentyl-1H-indole-2,3-dione, and 1,3-benzodioxol-5-ol with 3-chloro-4-fluorophenol, the title compound was obtained (14%): MS (ES+) m/z 346 (M−17), 386 (M+23).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08466188B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-057d2dcd1a45479b9fee2ea3adf79b66 |
| Source note | uspto-grants-2013_06 |