反应详情

温度

60 °C

2-phenyl-4-quinolinecarbonyl chloride (2.00 g, 7.47 mmol) was added in small portions to a pyridine (40 mL) solution of commercially available 2-amino-5-(2-furyl)-1,3,4-oxadiazole (1.69 g, 11.2 mmol), and the mixture was heated with stirring at 60° C. for 6 hours. To the reaction solution, methanol was added, and the solvent was distilled off. The obtained residue was triturated by the addition of water. The deposited crystal was collected by filtration, washed with methanol and then with ethyl acetate, and then recrystallized from DMF-methanol to obtain the title compound (1.23 g, 3.22 mmol) as a light brown powder (yield: 43%).

1. temperaturethe mixture was heated
2. distillationthe solvent was distilled off
3. customThe obtained residue was triturated by the addition of water
4. filtrationThe deposited crystal was collected by filtration
5. washwashed with methanol
6. customwith ethyl acetate, and then recrystallized from DMF-methanol