1-Hydroxybenzotriazole → HCID 67203980, compound

HRID 1259846Notes

Reaction equation

HRID 1259846 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)[CH:6]=[C:5]2[C:17]([OH:19])=O.CN(C(ON1[N:36]=[N:35][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=CC2N([OH:53])N=NC=2C=1.C[N:55]([C:57]([O:61]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=NC2N(O)N=NC=2C=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)[CH:6]=[C:5]2[C:17]([NH:55][C:57]1[O:61][C:30]([C:31]2[O:53][CH:34]=[CH:33][CH:32]=2)=[N:35][N:36]=1)=[O:19]

Participants

6

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 181649HOAtHCID 6258076-Chloro-2-(thiophen-2-yl)quinoline-4-carboxylic acidHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

Product 1

HCID 67203980HCID 67203980, compound

Procedure

The title compound was synthesized according to the synthesis method of a compound Ia-46 described later using commercially available 6-chloro-2-(2-thienyl)-4-quinolinecarboxylic acid, HBTU, and HOBt instead of 2-(4-fluorophenyl)-4-quinolinecarboxylic acid, HATU, and HOAt, respectively.

Workup

  1. customaccording to the synthesis method of a compound Ia-46

Sources & evidence

ORD record
ord-9b4df73b48904bb7ad77bf579f2f051c
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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