反应详情

Triphenylphosphine bromide (352 mg, 0.80 mmol) was added to a methylene chloride (1 mL) solution of commercially available 8-methyl-2-(2-thienyl)-4-quinolinecarboxylic acid (108 mg, 0.40 mmol), and the mixture was stirred at room temperature for 1 hour. The reaction solution was added to a pyridine (3 mL) solution of 2-amino-5-(2-furyl)-1,3,4-oxadiazole (90.7 mg, 0.60 mmol), and the mixture was stirred at room temperature for 2 hours and then heated with stirring overnight at 60° C. The reaction solution was concentrated. After that, to the residue, water was added, and the deposited solid was collected by filtration, washed with water, dried, and then purified by preparative HPLC to obtain the title compound (22 mg, 0.05 mmol).

1. stirringthe mixture was stirred at room temperature for 2 hours
2. temperatureheated
3. stirringwith stirring overnight at 60° C
4. concentrationThe reaction solution was concentrated
5. additionAfter that, to the residue, water was added
6. filtrationthe deposited solid was collected by filtration
7. washwashed with water
8. customdried
9. custompurified by preparative HPLC