1-Hydroxybenzotriazole → HCID 67203723, compound

HRID 1259852Notes

Reaction equation

HRID 1259852 reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:18]([OH:20])=O.CN(C(ON1[N:37]=[N:36][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=CC2N([OH:54])N=NC=2C=1.C[N:56]([C:58]([O:62]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1C=NC2N(O)N=NC=2C=1>>[O:54]1[CH:35]=[CH:34][CH:33]=[C:32]1[C:31]1[O:62][C:58]([NH:56][C:18]([C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([I:1])[CH:3]=3)[N:8]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:6]=2)=[O:20])=[N:37][N:36]=1

Participants

6

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 181649HOAtHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 19955783HCID 19955783, compound

Product 1

HCID 67203723HCID 67203723, compound

Procedure

The title compound was synthesized according to the synthesis method of the compound Ia-46 using 6-iodo-2-phenyl-4-quinolinecarboxylic acid described in Reference Example 18, HBTU, and HOBt instead of 2-(4-fluorophenyl)-4-quinolinecarboxylic acid, HATU, and HOAt, respectively.

Workup

  1. customaccording to the synthesis method of the compound

Sources & evidence

ORD record
ord-11fdc574d51b4d77b1086c2fd3cf06c0
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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