HCID 86655537, compound → HCID 67204698, compound

HRID 1259854Notes

Reaction equation

HRID 1259854 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:18]([NH:20][C:21](=S)[NH:22][NH:23][C:24]([C:26]1[S:27][CH:28]=[CH:29][CH:30]=1)=[O:25])=[O:19].C1(C2C=C(C(NC(=S)NNC(C3SC=CC=3)=O)=O)C3C(=CC=C(OC(F)(F)F)C=3)N=2)C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:6]=[C:5]2[C:18]([NH:20][C:21]1[O:25][C:24]([C:26]2[S:27][CH:28]=[CH:29][CH:30]=2)=[N:23][N:22]=1)=[O:19]

Participants

3

Reactant 2

HCID 86655537HCID 86655537, compoundHCID 86655538HCID 86655538, compound

Product 1

HCID 67204698HCID 67204698, compound

Procedure

The title compound was synthesized according to the synthesis method of a compound Ia-122 described later using 4-(6-chloro-2-phenyl-4-quinolinecarbonyl)-1-(2-thiophenecarbonyl)thiosemicarbazide described in Reference Example 37 instead of 4-(2-phenyl-6-trifluoromethoxy-4-quinolinecarbonyl)-1-(2-thiophenecarbonyl)thiosemicarbazide.

Workup

  1. customaccording to the synthesis method of a compound Ia-122

Sources & evidence

ORD record
ord-696e71deca124adca95d6c6559c92fc7
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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