Acetic Anhydride → HCID 67204263, compound

HRID 1259863Notes

Reaction equation

HRID 1259863 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH2:8]([O:15][C:16]([C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=[C:20]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[OH:34])[CH:19]=1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[CH2:8]([O:15][C:16]([C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:21]=[C:20]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[O:34][C:1](=[O:3])[CH3:2])[CH:19]=1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 136331178HCID 136331178, compound

Product 1

HCID 67204263HCID 67204263, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetic anhydride (1 mL) was added to a pyridine (10 mL)) solution of 2-(2-hydroxyphenyl)-4-quinolinecarboxylic acid benzyl ester (1.09 g, 3.07 mmol) obtained above, and the mixture was stirred at room temperature for 7 hours. The reaction solution was concentrated, and then, the residue was purified by silica gel column chromatography to obtain 2-(2-acetoxyphenyl)-4-quinolinecarboxylic acid benzyl ester (940 mg, 2.34 mmol).

Workup

  1. customobtained above, and the mixture
  2. concentrationThe reaction solution was concentrated
  3. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-d4639c2e28e247e1b3c0082b34a93eaf
Source dataset
uspto-grants-2013_06
Patent number
US08466290B2

Reaction notes

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