Hydrogen chloride-ethyl acetate → HCID 178495052, compound

HRID 1259950Notes

Reaction equation

HRID 1259950 reaction equation
[F:1][C:2]1[C:7]2[N:8]([CH2:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:9]([C:11]([N:13]([CH2:32][CH:33]([CH3:35])[CH3:34])[C@H:14]3[CH2:19][C@@H:18]([C:20]4[NH:24][CH:23]=[N:22][N:21]=4)[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]3)=[O:12])=[N:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(OCC)(=O)C.[ClH:48]>>[ClH:48].[ClH:48].[F:1][C:2]1[C:7]2[N:8]([CH2:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:9]([C:11]([N:13]([CH2:32][CH:33]([CH3:34])[CH3:35])[C@H:14]3[CH2:19][C@@H:18]([C:20]4[NH:24][CH:23]=[N:22][N:21]=4)[CH2:17][NH:16][CH2:15]3)=[O:12])=[N:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178495050HCID 178495050, compound

Product 1

HCID 178495052HCID 178495052, compound

Procedure

tert-Butyl (3S,5R)-3-{{{7-fluoro-1-(4-methoxybutyl)-1H-benzimidazol-2-yl}carbonyl}(2-methylpropyl)amino}-5-(4H-1,2,4-triazol-3-yl)piperidine-1-carboxylate (130 mg) was dissolved in 2M hydrogen chloride-ethyl acetate (3 ml), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated to give the object product (91 mg).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-4dd3aa0ce9994513981d8549e0ad8f3f
Source dataset
uspto-grants-2013_06
Patent number
US08466282B2

Reaction notes

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