反应详情

To a solution of ethyl 3-(hydroxymethyl)imidazo[1,2-a]pyridine-2-carboxylate (2.85 g) in chloroform (40 ml) was added thionyl chloride (8.0 ml) at room temperature, and the mixture was heated under reflux for 12 hr. The reaction solution was cooled to room temperature, and concentrated under reduced pressure. The precipitated crystals were collected by filtration, washed with diethyl ether to give the object product (3.50 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 12 hr
3. concentrationconcentrated under reduced pressure
4. filtrationThe precipitated crystals were collected by filtration
5. washwashed with diethyl ether