Hydrogen chloride-ethyl acetate → HCID 67321216, Verbindung

HRID 1260101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260101
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:10]=[N:9][C:8]=1[C:18]([N:20]([CH2:41][CH:42]([CH3:44])[CH3:43])[C@H:21]1[CH2:26][C@@H:25]([C:27]([N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[O:28])[CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]1)=[O:19].C(OCC)(=O)C.[ClH:51]>C(OCC)(=O)C>[ClH:51].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:10]=[N:9][C:8]=1[C:18]([N:20]([CH2:41][CH:42]([CH3:44])[CH3:43])[C@H:21]1[CH2:26][C@@H:25]([C:27]([N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[O:28])[CH2:24][NH:23][CH2:22]1)=[O:19]

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58355108HCID 58355108, Verbindung

Produkt 1

HCID 67321216HCID 67321216, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

tert-Butyl (3S,5R)-3-[{[5-(4-methoxybutyl)-1-phenyl-1H-1,2,3-triazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(pyrrolidin-1-ylcarbonyl)piperidine-1-carboxylate (245 mg) was dissolved in ethyl acetate (0.5 ml), 4N hydrogen chloride-ethyl acetate solution (0.5 ml) was added, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was dried under reduced pressure to give the object product (205 mg).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d2f90e3eba504a8f8c93fafe80de8422
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466282B2

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