反应详情

KMUP-1 (8.0 g) is dissolved in a mixture of ethanol (100 mL) and water (30 mL), to which repaglinide (9.1 g) dissolved in ethyl alcohol (150 mL) is added, and the mixture is reacted at 50° C. for 20 mins. The precipitate is obtained through filtering under room temperature, which is re-crystallized from methanol over night at room temperature and then filtrated to obtain KMUP-1-repaglinide complex (15.3 g).

1. additionis added
2. customthe mixture is reacted at 50° C. for 20 mins
3. customThe precipitate is obtained
4. filtrationthrough filtering under room temperature
5. customwhich is re-crystallized from methanol over night at room temperature
6. filtrationfiltrated
7. customto obtain KMUP-1-repaglinide complex (15.3 g)