3-((Tert-butyldiphenylsilyl)oxy)azetidine → HCID 54591440, compound

Participants

Reaction Steps

Analogously to the process described in Example 1, 500 mg (0.993 mmol) of the compound from Example 2A and 464 mg (1.49 mmol) of the compound from Example 8A were used to obtain 289 mg (58% of theory) of the title compound. It was possible here to dispense with the second component step of the process (silyl ether cleavage with TBAF), since the protecting group had already been detached in the course of the first component step. The crude product was purified by means of MPLC (silica gel, eluent: 1:1 cyclohexane/ethyl acetate) and subsequent extractive stirring in a mixture of 25 ml of pentane, 1 ml of diisopropyl ether and 125 μl of dichloromethane.

Provenance & Evidence