3-((Tert-butyldiphenylsilyl)oxy)azetidine → HCID 54591372, compound

HRID 1260190Notes

Reaction equation

HRID 1260190 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[Si]([O:49][CH:50]1[CH2:53][NH:52][CH2:51]1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH3:11][C:10]1[N:6]([CH2:5][C:4]2[CH:3]=[C:2]([N:52]3[CH2:53][CH:50]([OH:49])[CH2:51]3)[CH:31]=[CH:30][CH:29]=2)[N:7]=[C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 178425313-((Tert-butyldiphenylsilyl)oxy)azetidineHCID 58072142HCID 58072142, compound

Product 1

HCID 54591372HCID 54591372, compound

Procedure

Analogously to the process described in Example 3, 150 mg (0.313 mmol) of the compound from Example 4A and 146 mg (0.469 mmol) of the compound from Example 8A were used to obtain 77 mg (52% of theory) of the title compound.

Sources & evidence

ORD record
ord-67d626e40f024977a2018a2798a58392
Source dataset
uspto-grants-2013_06
Patent number
US08470811B2

Reaction notes

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