3-((Tert-butyldiphenylsilyl)oxy)azetidine → HCID 54591373, compound

HRID 1260191Notes

Reaction equation

HRID 1260191 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4([F:29])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[Si]([O:50][CH:51]1[CH2:54][NH:53][CH2:52]1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[F:29][C:23]1([C:20]2[CH:21]=[CH:22][C:17]([C:14]3[N:13]=[C:12]([C:8]4[CH:9]=[C:10]([CH3:11])[N:6]([CH2:5][C:4]5[CH:3]=[C:2]([N:53]6[CH2:54][CH:51]([OH:50])[CH2:52]6)[CH:32]=[CH:31][CH:30]=5)[N:7]=4)[O:16][N:15]=3)=[CH:18][CH:19]=2)[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 178425313-((Tert-butyldiphenylsilyl)oxy)azetidineHCID 58072153HCID 58072153, compound

Product 1

HCID 54591373HCID 54591373, compound

Procedure

Analogously to the process described in Example 3, 150 mg (0.302 mmol) of the compound from Example 5A and 141 mg (0.452 mmol) of the compound from Example 8A were used to obtain 62 mg (42% of theory) of the title compound.

Sources & evidence

ORD record
ord-f4726e52fa1f4d00b60ba81a0921fbf0
Source dataset
uspto-grants-2013_06
Patent number
US08470811B2

Reaction notes

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