3-((Tert-butyldiphenylsilyl)oxy)azetidine → HCID 54591374, compound

HRID 1260192Notes

Reaction equation

HRID 1260192 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4([F:27])[CH2:26][O:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[Si]([O:48][CH:49]1[CH2:52][NH:51][CH2:50]1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[F:27][C:23]1([C:20]2[CH:21]=[CH:22][C:17]([C:14]3[N:13]=[C:12]([C:8]4[CH:9]=[C:10]([CH3:11])[N:6]([CH2:5][C:4]5[CH:3]=[C:2]([N:51]6[CH2:52][CH:49]([OH:48])[CH2:50]6)[CH:30]=[CH:29][CH:28]=5)[N:7]=4)[O:16][N:15]=3)=[CH:18][CH:19]=2)[CH2:26][O:25][CH2:24]1

Participants

3

Reactant 2

HCID 178425313-((Tert-butyldiphenylsilyl)oxy)azetidineHCID 58072145HCID 58072145, compound

Product 1

HCID 54591374HCID 54591374, compound

Procedure

Analogously to the process described in Example 3, 150 mg (0.320 mmol) of the compound from Example 6A and 149 mg (0.479 mmol) of the compound from Example 8A were used to obtain 60 mg (39% of theory) of the title compound.

Sources & evidence

ORD record
ord-2c813982ff9f42c5a64803a24b33511d
Source dataset
uspto-grants-2013_06
Patent number
US08470811B2

Reaction notes

Loading…