3-((Tert-butyldiphenylsilyl)oxy)azetidine → HCID 54591375, compound

HRID 1260193Notes

Reaction equation

HRID 1260193 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4([O:27][CH3:28])[CH2:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[Si]([O:49][CH:50]1[CH2:53][NH:52][CH2:51]1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH3:28][O:27][C:23]1([C:20]2[CH:21]=[CH:22][C:17]([C:14]3[N:13]=[C:12]([C:8]4[CH:9]=[C:10]([CH3:11])[N:6]([CH2:5][C:4]5[CH:3]=[C:2]([N:52]6[CH2:53][CH:50]([OH:49])[CH2:51]6)[CH:31]=[CH:30][CH:29]=5)[N:7]=4)[O:16][N:15]=3)=[CH:18][CH:19]=2)[CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 178425313-((Tert-butyldiphenylsilyl)oxy)azetidineHCID 58072143HCID 58072143, compound

Product 1

HCID 54591375HCID 54591375, compound

Procedure

Analogously to the process described in Example 3, 150 mg (0.313 mmol) of the compound from Example 7A and 146 mg (0.469 mmol) of the compound from Example 8A were used to obtain 53 mg (36% of theory) of the title compound.

Sources & evidence

ORD record
ord-7c9cd1b2bdb94b70a57a097456691170
Source dataset
uspto-grants-2013_06
Patent number
US08470811B2

Reaction notes

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