4-Cyanopiperidine → HCID 54591521, Verbindung

HRID 1260199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260199
Br[C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([CH3:29])([CH3:28])[C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[C:33]([CH:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)#[N:34]>>[CH3:11][C:10]1[N:6]([CH2:5][C:4]2[CH:3]=[C:2]([N:38]3[CH2:39][CH2:40][CH:35]([C:33]#[N:34])[CH2:36][CH2:37]3)[CH:32]=[CH:31][CH:30]=2)[N:7]=[C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([CH3:29])([CH3:28])[C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[N:13]=2)[CH:9]=1

Komponenten

3

Edukt 2

HCID 1382234-CyanopiperidineHCID 58072152HCID 58072152, Verbindung

Produkt 1

HCID 54591521HCID 54591521, Verbindung

Versuchsvorschrift

Analogously to the process described in Example 9, 125 mg (0.247 mmol) of the compound from Example 3A and 55 mg (0.495 mmol) of 4-cyanopiperidine were used to obtain 66 mg (50% of theory) of the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-e36423fe9a144632b7eac4ae20ae8980
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470811B2

Notizen zur Reaktion

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