4-Toluenesulfonyl chloride → 3-Fluoroprop-1-yl toluene-4-sulphonate

HRID 1260214ノート

反応式

HRID 1260214 の反応式
[F:1][CH2:2][CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[C:13]1([CH3:23])[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>ClCCl>[F:1][CH2:2][CH2:3][CH2:4][O:5][S:19]([C:16]1[CH:17]=[CH:18][C:13]([CH3:23])=[CH:14][CH:15]=1)(=[O:21])=[O:20]

参加物

5

反応物 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 680423-Fluoro-1-propanol

生成物 1

HCID 63667743-Fluoroprop-1-yl toluene-4-sulphonate収率 92.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5 g of 3-fluoro-propanol (64.03 mmol) and 18 ml of triethylamine (129.32 mmol) were dissolved in 50 ml of dichloromethane. At 0-5° C., 12.9 g toluene-4-sulfonylchloride (67.66 mmol) were added and the reaction mixture stirred at room temperature for 18 h. Standard work-up yielded 13.7 g of toluene-4-sulfonic acid 3-fluoro-propyl ester.

出典と根拠

ORDレコード
ord-1fca095e8f614343a85d7a1ea1634736
出典データセット
uspto-grants-2013_06
特許番号
US08470810B2

反応ノート

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