4-(3-Fluoropropyl)-benzenesulfonyl chloride → 4-(3-Fluoro-propyl)-N-[4-(1-propyl-azetidin-3-yl)-phenyl]-benzenesulfonamide

Participants

Reaction Steps

Following the same procedure as described in example 55, 4-(1-propyl-azetidin-3-yl)phenylamine (100 mg, 0.52 mmol) in CH2Cl2/pyridine 1:1 (12 ml) was treated with 4-(3-fluoro-propyl)-benzenesulfonyl chloride (161 mg, 0.68 mmol). Purification of the crude product by chromatography on reversed phase silica gel (H2O+0.1% acetic acid:CH3CN+0.1% acetic acid, 75:25) provided the title compound (40 mg, 20%) as a colourless gum.

Provenance & Evidence