p-Bromobenzenesulfonyl chloride → 4-Bromo-N-[4-(1-propyl-azetidin-3-yl)-phenyl]-benzenesulfonamide

Participants

Reaction Steps

Following the same procedure as described in example 55, 4-(1-propyl-azetidin-3-yl)phenylamine (1 g, 5.25 mmol) in CH2Cl2/pyridine 9:1 (50 ml) was treated with 4-bromobenzenesulfonyl chloride (1.34 g, 5.25 mmol). Purification of the crude product by flash column chromatography (CH2Cl2:methanol, 95:5) provided the title compound (1.1 g, 51%) as a colourless gum.

Provenance & Evidence