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HRID1260250

反应详情

EQUATION

反应方程式

HRID 1260250 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](CF)c1ccc(S(=O)(=O)Cl)cc1
HCID53628600

未命名化合物

结构：CCCN1CC(c2ccc(N)cc2)C1
HCID57470084

未命名化合物

PRODUCTS

生成物

1
结构：CCCN1CC(c2ccc(NS(=O)(=O)c3ccc([C@H](C)CF)cc3)cc2)C1
HCID67071391

未命名化合物

收率 22.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.c1ccncc1
溶剂HCID21875418

未命名化合物

PROCEDURE

实验过程

Following the same procedure as described in example 55, 4-(1-propyl-azetidin-3-yl)phenylamine (110 mg, 0.57 mmol) in CH2Cl2/pyridine 1:1 (12 ml) was treated with 4-((S)-2-fluoro-1-methyl-ethyl)-benzenesulfonyl chloride (178 mg, 0.75 mmol). Purification of the crude product by flash column chromatography (CH2Cl2:methanol, 95:5) provided the title compound (50 mg, 22%) as a gum.

WORKUP

后处理

  1. customPurification of the crude product by flash column chromatography (CH2Cl2:methanol, 95:5)