HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 53628606, compound → HCID 53628673, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 53628606 | HCID 53628606 | — |
| Reactant | HCID 57470084 | HCID 57470084 | — |
| Solvent | Pyridine methylene chloride | HCID 21875418 | — |
| Product | HCID 53628673 | HCID 53628673 | 11.7% |
Reaction Steps
Following the same procedure as described in example 55, 4-(1-propyl-azetidin-3-yl)phenylamine (100 mg, 0.52 mmol) in CH2Cl2/pyridine 9:1 (12 ml) was treated with 4-(3,3,3-trifluoro-propyl)-benzenesulfonyl chloride (214 mg, 0.78 mmol). Purification of the crude product by flash column chromatography (CH2Cl2:methanol, 95:5) provided the title compound (26 mg, 11%) as a colourless gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470810B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-06d3c31277a6427e95f01a293718b4ee |
| Source note | uspto-grants-2013_06 |