反应详情

A solution of 1-tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate (1.00 equiv.) and hydrazine (excess of 50% aq. solution) in ethanol (0.2 M final conc.) is heated to reflux. After the reaction is deemed complete, the reaction mixture is cooled to rt and partially concentrated. The resulting mixture is diluted with EtOAc, and the resulting organics are washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound i-12a.

1. concentrationpartially concentrated
2. additionThe resulting mixture is diluted with EtOAc
3. washthe resulting organics are washed with water and brine
4. dry with materialdried (sodium sulfate)
5. concentrationconcentrated in vacuo