HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinoethanol → 2-[5-amino-3-(pyridin-2-yl)-1H-pyrazol-1-yl]ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinoethanol | HCID 8017 | — |
| Reactant | 3-Oxo-3-(pyridin-2-yl)propanenitrile | HCID 11571823 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[5-amino-3-(pyridin-2-yl)-1H-pyrazol-1-yl]ethan-1-ol | HCID 62825488 | 80.6% |
Reaction Steps
A solution of 3-oxo-3-pyridin-2-yl-propionitrile (0.5 g, 3.4 mmol; CAS 54123-21-6) in EtOH (20 ml) was treated with 2-hydroxyethylhydrazine (0.7 ml, 10.3 mmol). The reaction mixture was refluxed overnight, then concentrated. After silica gel chromatography using a CH2Cl2/MeOH gradient, the product was obtained as viscous yellow oil (0.56 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470820B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-99d03ce82d7e425883dd325908a8281c |
| Source note | uspto-grants-2013_06 |