反应详情

To a stirred solution of (Z)-4-hydroxy-2-oxo-4-pyridin-2-yl-but-3-enoic acid ethyl ester (2.32 g, 10 mmol) at r.t. in EtOH (15 ml) under an argon atmosphere was added methylhydrazine (0.55 ml, 10 mmol). The mixture was heated to reflux and stirring was continued for 90 min. The mixture was cooled to r.t. and concentrated to leave a brown paste. After silica gel chromatography using a CH2Cl2/MeOH gradient, the product (1.43 g, 59%) was obtained as yellow waxy solid. MS: M=232.1 (M+H)+

1. temperatureThe mixture was heated
2. temperatureto reflux
3. concentrationconcentrated
4. customto leave a brown paste