HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenacyl bromide → [3-Amino-4-ethyl-5-(4-phenoxy-phenylamino)-thiophen-2-yl]-phenyl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | Propionitrile | HCID 7854 | — |
| Reactant | Butyronitrile | HCID 8008 | — |
| Reactant | Cyclopentyl isothiocyanate | HCID 141792 | — |
| Reactant | 1-Isothiocyanato-4-phenoxybenzene | HCID 145694 | — |
| Reactant | 5-(Bromoacetyl)-3-phenylisoxazole | HCID 2735532 | — |
| Product | [3-Amino-4-ethyl-5-(4-phenoxy-phenylamino)-thiophen-2-yl]-phenyl-methanone | HCID 57837075 | — |
Reaction Steps
[3-Amino-4-ethyl-5-(4-phenoxy-phenylamino)-thiophen-2-yl]-phenyl-methanone was prepared as described in Example 43 substituting Propanenitrile, Isothiocyanato-cyclopentane and 2-Bromo-1-(3-phenyl-isoxazol-5-yl)-ethanone with butanenitrile, 4-phenoxyphenylisothiocyanate and 2-Bromo-1-phenyl-ethanone respectively to provide compound 1-243. MS (ESI) [M+H+]+=415.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470821B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-f6f596802c31474eb7b7c8c48449808e |
| Source note | uspto-grants-2013_06 |