Sodium Methoxide → HCID 87530940, compound

Participants

Reaction Steps

A solution of Example 2 (0.35 g, 1.023 mmol) and sodium methoxide (25% wt/wt, 5.11 mmol) in methanol (10 mL) was heated to 50° C. for 2 hours. The mixture was concentrated to dryness under reduced pressure, taken up in DCM (100 mL), washed with water and brine. The organic phase was dried over sodium sulfate, filtered and concentrated to dryness under reduced pressure. The residue was purified by column chromatography using DCM as eluant to provide the titled compound. 1H NMR (CDCl3) δ ppm 1.31 (3H), 2.2 (3H), 4.27 (2H), 6.65 (1H), 7.05-7.25 (3H); MS (ESI) 343 (M+H).

Provenance & Evidence