Pyrrolidine → HCID 178474509, compound

Participants

Reaction Steps

The allyl chloride (Example 24A, 16 mg, 46 μmol) was dissolved into pyrrolidine (200 μL) and stirred 10 minutes. Then the mixture was twice diluted with and concentrated from EtOAc, and partitioned between 2:1 EtOAc/hexanes (1.5 mL) and water (1 mL). The organic phase was separated and washed with water, dried (Na2SO4), and chromatographed on silica (2 to 5% MeOH/CH2Cl2) to give the titled compound. 1H NMR (300 MHz, CDCl3) δ ppm 1.81 (4 H), 2.22 (3 H), 2.60 (4 H), 3.66 (2 H), 6.91 (1 H), 7.17 (2 H), 7.36 (1 H); MS (ESI) 382 (M+H)+.

Provenance & Evidence