Triethylamine → HCID 178429850, compound

Participants

Reaction Conditions

Reaction Steps

The imine (Example 26A, 30 mg, 0.09 mmol) was dissolved in 1.5 ml acetonitrile (1.5 mL). Triethylamine (19 μl, 0.18 mmol) was added followed by the cyclobutanecarbonyl chloride (0.11 mmol). The reaction was heated at 65° C. overnight. The reaction mixture was cooled down and passed through a Si-amine cartridge (1 g, 1.6 mmol/g) to remove the excess carbonyl chloride eluting with additional acetonitrile. The resulting solution was dried and purified by reverse phase HPLC. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.75 (1 H), 1.88 (1 H), 2.10 (4 H), 2.26 (3 H), 3.15 (1 H), 7.44 (1 H), 7.63 (1 H), 7.68 (1 H), 7.90 (1 H); MS (ESI) m/z 403.0 (M+H)+.

Provenance & Evidence