Diisopropylethylamine → HCID 87464014, compound

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Reaction Steps

A solution of (Z)-3-methyl-1-(5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiazol-2(3H)-ylidenecarbamoyl)-1H-imidazol-3-ium iodide (Example 81A, 0.1 g, 0.18 mmol), (S)-pyrrolidin-3-ol (0.016 g, 0.18 mmol) and Hunig's base (0.023 g, 018 mmol) in dry acetonitrile (5 mL) was heated to 60° C. for three hours. After cooling, the mixture was diluted with CH2Cl2 (50 mL) and washed with water and brine. The organic phase was dried over sodium sulfate, filtered and dried. After evaporation under reduced pressure, the residue was chromatographed over silica using CH2Cl2 and then 2% MeOH/CH2Cl2 to give the titled compound. 1H NMR (CDCl3) δ ppm 1.99 (2 H), 2.20 (3 H), 3.40-3.70 (4 H), 4.42 (1 H), 6.60 (1 H), 7.20-7.50 (3 H); MS (ESI) m/z 434(M+H)+.

Provenance & Evidence