Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Butanedioic acid, 2-methyl-, 1,4-dimethyl ester | HCID 15350 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methylsuccinic acid | HCID 10349 | — |
Reaction Steps
Commercially available dimethyl methylsuccinate (1.57 g, 9.8 mmol) was dissolved in a 3:1 mixed solvent of tetrahydrofuran and water, and lithium hydroxide (4 g, 98 mmol) was added and stirred for 2 days at 40° C. under reflux. After completion of the reaction was confirmed by TLC, the residue was distilled under reduced pressure to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08470836B2 |
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| Source dataset | uspto-grants-2013_06 |
|---|
| ORD ID | ord-5c1c95c30a16424cb4d6a70811034722 |
|---|
| Source note | uspto-grants-2013_06 |
|---|
