HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-propanol → 5-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-propanol | HCID 29740 | — |
| Reactant | (S)-3-(2,3-Dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 24965731 | — |
| Reactant | 5-((4-Amino-2-fluorophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 135741654 | — |
| Product | 5-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | HCID 24967883 | — |
Reaction Steps
The title compound was prepared following the same procedure for the synthesis of Compound 5G using compound 5F and 1-bromopropan-2-ol as starting material. 1H NMR (400 MHz, CDCl3) δ 8.17 (s, 1H) 7.52 (m, 2H) 7.24 (t, J=8.84 Hz, 1H) 5.81 (s, 1H) 4.39 (m, 1H) 4.25 (m, 1H) 3.57 (m, 4H), 1.35 (d, J=6.32 Hz, 3H). [M+H] calc'd for C17H16FIN4O3, 471. found, 471.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470837B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-417a12b92aeb4113bac712ed8eef42cf |
| Source note | uspto-grants-2013_06 |