HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 40480512, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Amino-2-bromopyridine | HCID 642816 | — |
| Reactant | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 40480512 | HCID 40480512 | — |
Reaction Steps
To the solution of 2-bromopyridin-3-amine in DME (0.1M) were added 2M aqueous Na2CO3 solution (2 eq.) and (3-chlorophenyl)boronic acid (1.1 eq). The mixture was degassed and placed under an argon atmosphere. PdCl2(dppf) (0.02 eq) were added and the reaction was heated at reflux overnight under argon. After cooling the reaction was diluted with EtOAc and washed with water and brine, then dried and evaporated under reduced pressure to afford the titled compound which was used as such in the next step. MS (ES+) C11H9ClN2 requires 204, 206, found: 205, 207 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470823B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-0b69e2b684e5436d971ac1d6822a2cb1 |
| Source note | uspto-grants-2013_06 |