HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,2,2-Trifluoroethyl)aniline → (5SR,6RS)-8-Benzyl-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,2,2-Trifluoroethyl)aniline | HCID 14836858 | — |
| Reactant | 1-Benzyl-3-hydroxy-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 58056619 | — |
| Product | (5SR,6RS)-8-Benzyl-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 58056622 | — |
Reaction Steps
The title compound was prepared in analogy to example 1 step C from a mixture of (3RS,4SR)-1-benzyl-3-hydroxy-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester and 4-(2,2,2-trifluoro-ethyl)-phenylamine). Light yellow solid. MS (ESI): 419.3 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470843B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-5e3da13235a745d295a1b52781aee600 |
| Source note | uspto-grants-2013_06 |