HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzenesulfonyl chloride → (5RS,6RS)-8-(2-Chloro-benzenesulfonyl)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzenesulfonyl chloride | HCID 76187 | — |
| Reactant | HCID 58056621 | HCID 58056621 | — |
| Product | (5RS,6RS)-8-(2-Chloro-benzenesulfonyl)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 56602712 | — |
Reaction Steps
The title compound was prepared in analogy to example 2 step B from a mixture of (5SR,6RS)-6-hydroxy-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (described in example 7 step B) and 2-chloro-benzenesulfonyl chloride. Colourless solid. MS (ESI): 503.0 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08470843B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-7676fff6fe50459a99e0ade1f8e8eb03 |
| Source note | uspto-grants-2013_06 |